Acta Crystallographica Section D
Acta Crystallographica
Section D
STRUCTURAL BIOLOGY
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Acta Cryst.
(2014).
D
70
,
582-595
https://doi.org/10.1107/S1399004713030629
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Elements in nucleotide sensing and hydrolysis of the AAA+ disaggregation machine ClpB: a structure-based mechanistic dissection of a molecular motor
C. Zeymer
,
T. R. M. Barends
,
N. D. Werbeck
,
I. Schlichting
and
J. Reinstein
High-resolution crystal structures together with mutational analysis and transient kinetics experiments were utilized to understand nucleotide sensing and the regulation of the ATPase cycle in an AAA+ molecular motor.
Keywords:
ClpB
;
AAA+ protein
;
molecular chaperones
;
molecular motors
;
transient kinetics
;
enzyme mechanisms
;
nucleotide sensing
.
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