Nitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition state

A nitrate molecule was found in both the open and closed form of the catalytic site of PTP1B. This complex was modelled using quantum mechanics and compared to the crystal structure.

Unprecedented conformational flexibility revealed in the ligand-binding domains of the Bovicola ovis ecdysone receptor (EcR) and ultraspiracle (USP) subunits

The crystal structure of the heterodimeric ligand-binding domains of the B. ovis ecdysone receptor was solved in the presence of an ecdysteroid and a synthetic methylene lactam insecticide, respectively. Analysis of these structures reveals a new level of conformational flexibility for the ecdysone receptor upon binding of ligands.

The structure of vanin 1: a key enzyme linking metabolic disease and inflammation

The structure of vanin 1, a human ectoenzyme involved in inflammation and metabolic disease, is shown to be regulated by an unusual allosteric mechanism.