Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Acta Cryst. (2012). D68, 1479-1487
https://doi.org/10.1107/S0907444912037171

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A monomeric TIM-barrel structure from Pyrococcus furiosus is optimized for extreme temperatures

H. Repo, J. S. Oeemig, J. Djupsjöbacka, H. Iwaï and P. Heikinheimo

The TrpF structure from the hyperthermophilic archaeon P. furiosus is described at 1.75 Å resolution. Structural comparison with other thermophilic TrpF proteins suggests a mechanism for thermal stability.

Keywords: α/β barrels; hyperthermophiles; TrpF; isomerases; protein engineering.

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