research papers
The first structure of a subfamily 4 peptaibol antibiotic, trichovirin I-4A, is described at atomic resolution. The structure suggests a conformational transition to obtain the necessary amphiphilicity for membrane insertion and water/ion transport across the hydrophobic barrier.
research papers
Macromolecular crystals luminesce during X-ray irradiation. This luminescence, and how it changes as a function of absorbed dose, has been characterized for several different proteins.
research papers
A sample environment for mounting crystallization trays has been developed on the microfocus beamline I24 at Diamond Light Source. The technical developments and several case studies are described.
research papers
A systematic increase in lifetime is observed in room-temperature protein and virus crystals through the use of reduced exposure times and a fast detector.