Does the size of a crystal matter in an X-ray crystal structure analysis of a small molecule?

Five crystals whose compositions represent typical small molecules refined to low R values despite being only partially bathed by the X-ray beam, the refinement differing little for the large crystal compared with that for a small crystal. Intensity measurements of crystals that are larger than the beam can be regarded as being satisfactory for light-atom structures whose intensities have been corrected by multi-scan methods; however, the measurements are better corrected by numerical methods, particularly for heavy-atom structures.