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The asymmetric unit of the title hydrated salt, C22H26F2NO4+·Cl·0.5H2O, consists of an (S,S,S,S)-nebivolol {nebivol = bis­[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hy­droxy­eth­yl]ammonium} cation, a chloride anion and a half-occupancy water mol­ecule. The dihedral angle between the mean planes of the benzene rings is 50.34 (12)°. The pyran rings adopt half-chair conformations. The crystal packing features O—H...O hydrogen bonds and weak N—H...Cl, O—H...Cl, and O—H...Cl inter­actions, producing layers along (010).
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