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In the title compound, C24H27BrN4O4S2, the molecule is twisted at the sulfonyl S atom with a C—S(O2)—N(H)—C torsion angle of 62.6 (3)°. The benzene rings bridged by the sulfonamide group are tilted to each other by a dihedral angle of 60.6 (1)°. The dihedral angle between the sulfur-bridged pyrimidine and benzene rings is 62.7 (1)°. The morpholine ring adopts a chair conformation. The molecular conformation is stabilized by a weak intramolecular π–π stacking interaction between the pyrimidine and the 2,4,6-trimethylbenzene rings [centroid–centroid distance = 3.793 (2) Å]. In the crystal, molecules are linked by N—H
O hydrogen bonds into a chain along the b axis.
O hydrogen bonds into a chain along the b axis.organic compoundsOpen access
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In the title compound, C14H12ClNO, the dihedral angle between the aromatic rings is 39.84 (7)°. In th crystal, molecules are connected by O—HN hydrogen bonds into chains parallel to [001]. In addition, a C—Hπ contact occurs.
N hydrogen bonds into chains parallel to [001]. In addition, a C—Hπ contact occurs. organic compoundsOpen access
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The title compound, C22H23BrN4O3S2, crystallizes with two molecules, A and B, in the asymmetric unit. In one of these, the methoxy group is disordered over two sets of sites in a 0.565 (9):0.435 (9) ratio. The benzene rings bridged by the sulfonamide group are tilted relative to each other by 37.4 (1) and 56.1 (1)° in molecules A and B, respectively, while the dihedral angles between the sulfur-bridged pyrimidine and benzene rings are 72.4 (1) and 70.2 (1)° for A and B, respectively. The piperidine ring adopts a chair conformation in both molecules. In the crystal, inversion dimers linked by pairs of N—HN hydrogen bonds occur for both A and B; the dimers are linked into [010] chains by C—HO hydrogen bonds. The crystal structure also features inversion-generated aromatic π–π stacking interactions between the pyrimidine rings for both molecules [centroid–centroid distances = 3.412 (2) (molecule A) and 3.396 (2) Å (molecule B)].
N hydrogen bonds occur for both A and B; the dimers are linked into [010] chains by C—HO hydrogen bonds. The crystal structure also features inversion-generated aromatic π–π stacking interactions between the pyrimidine rings for both molecules [centroid–centroid distances = 3.412 (2) (molecule A) and 3.396 (2) Å (molecule B)].
