3-[(N-Methyl­anilino)meth­yl]-5-(thio­phen-2-yl)-1,3,4-oxadiazole-2(3H)-thione

In the title compound, C₁₄H₁₃N₃OS₂, the thio­phene ring is disordered over two orientations by ca 180° about the C—C bond axis linking the ring to the rest of the mol­ecule, with a site-occupancy ratio of 0.651 (5):0.349 (5). The central 1,3,4-oxadiazole-2(3H)-thione ring forms dihedral angles of 9.2 (5), 4.6 (11) and 47.70 (7)° with the major and minor parts of the disordered thio­phene ring and the terminal phenyl ring, respectively. In the crystal, no significant inter­molecular hydrogen bonds are observed. The crystal packing is stabilized by π–π inter­actions [centroid–centroid distance = 3.589 (2) Å].

Methyl 2-({6-[(1-meth­oxy-2-methyl-1-oxopropan-2-yl)carbamo­yl]pyridin-2-yl}formamido)-2-methyl­propano­ate

In the title compound, C₁₇H₂₃N₃O₆, the two meth­oxy­carbonyl C—O—C=O planes are inclined at dihedral angles of 5.3 (4) and 83.9 (4)° with respect to the central pyridine ring. An intra­molecular N—H...O hydrogen bond generates an S(5) ring motif. In the crystal, mol­ecules are linked into a chain along the c axis via C—H...O hydrogen bonds.

(E)-2-Cyano-N′-(1,2,3,4-tetra­hydro­naphthalen-1-yl­idene)acetohydrazide

In the title compound, C₁₃H₁₃N₃O, the tetra­hydro­benzene ring adopts a half-boat (envelope) conformation. The mean plane of the tetra­hydro­naphthalene ring system forms a dihedral angle of 9.56 (6)° with the mean plane of the cyano­acetohydrazide group. In the crystal, inversion dimers linked by pairs of N—H...O hydrogen bonds generate R₂²(8) loops. The dimers are connected by C—H...N hydrogen bonds into a chain propagating along [101]. The crystal packing also features C—H...π inter­actions.

3-(Adamantan-1-yl)-1-[(4-benzyl­piperazin-1-yl)meth­yl]-4-[(E)-(2-hy­droxy­benzyl­idene)amino]-1H-1,2,4-triazole-5(4H)-thione

In the title compound, C₃₁H₃₈N₆OS, the conformation about the N=C [1.285 (2) Å] imine bond is E. The piperazine ring has a chair conformation and occupies a position almost perpendicular to the plane through the triazole ring; the benzene ring forms a dihedral angle of 31.95 (10)° with the triazole ring. Overall, the mol­ecule has the shape of a flattened bowl. The hy­droxy group is disordered over two positions. The major component has a site-occupancy factor of 0.762 (3) and forms an intra­molecular O—H...N(imine) bond to close an S(6) loop. The minor component of the disordered hy­droxy group forms an O—H...N(piperazine) hydrogen bond. These, along with C—H...S and C—H...N inter­actions, link mol­ecules into a three-dimensional architecture.

3-(Adamantan-1-yl)-4-methyl-1-[(4-phenyl­piperazin-1-yl)meth­yl]-1H-1,2,4-triazole-5(4H)-thione dichloro­methane hemisolvate

The asymmetric unit of the title dichloro­methane hemisolvate, C₂₄H₃₃N₅S·0.5CH₂Cl₂, comprises an adamantan­yl/triazole derivative and half a CH₂Cl₂ mol­ecule of crystallization; the latter is disordered about a twofold axis of symmetry. The piperazine ring has a chair conformation and the two N-bound substituents occupy equatorial positions. The piperazine residue is almost normal to the triazole ring [N—N—C—N torsion angle = −79.9 (3)°] so that to a first approximation, the mol­ecule has an L-shape. Linear supra­molecular chains parallel to [001] are formed via C—H...S inter­actions. Two such chains are linked into a double chain via C—H...Cl inter­actions involving the disordered CH₂Cl₂ mol­ecules of solvation.

Ethyl 2-amino-4-(4-fluoro­phen­yl)-6-meth­oxy-4H-benzo[h]chromene-3-carboxyl­ate

In the title compound, C₂₃H₂₀FNO₄, the fluoro-substituted benzene ring is approximately perpendicular to the mean plane of the 4H-benzo[h]chromene ring system [maximum deviation = 0.264 (1) Å], with a dihedral angle of 83.79 (6)°. The pyran ring adopts a flattened boat conformation. The meth­oxy group is slightly twisted from the attached benzene ring of the 4H-benzo[h]chromene moiety [C—O—C—C = −2.1 (2)°]. An intra­molecular N—H...O hydrogen bond generates an S(6) ring motif. In the crystal, mol­ecules are linked by N—H...O and N—H...F hydrogen bonds into a layer parallel to the bc plane. The crystal packing also features C—H...π inter­actions.

Methyl 2-{6-[(1-meth­oxy-1-oxopropan-2-yl)amino­carbon­yl]pyridine-2-carboxamido}­propano­ate

In the title compound, C₁₅H₁₉N₃O₆, the amide planes are inclined at dihedral angles of 0.8 (6) and 12.1 (3)° with respect to the central pyridine ring. The mean planes of the corresponding methyl acetate groups form dihedral angles of 41.76 (13) and 86.48 (15)°, respectively with the mean plane of pyridine ring. A pair of weak intra­molecular N—H...N hydrogen bonds generate an S(5)S(5) ring motif in the mol­ecule. In the crystal, mol­ecules are linked by N—H...O hydrogen bonds into [001] chains. The chains are cross-linked by C—H...O hydrogen bonds into layers lying parallel to bc plane. The crystal packing also features a C—H...π inter­action.

2-{[2-Methyl-3-(2-methyl­phen­yl)-4-oxo-3,4-dihydro­quinazolin-8-yl]­oxy}acetonitrile

In the title compound, C₁₈H₁₅N₃O₂, the fused ring system is almost planar [the dihedral angle between the six-membered rings is 1.81 (6)°]. The 2-tolyl ring is approximately orthogonal to this plane [dihedral angle = 83.03 (7)°] as is the acetonitrile group [C—O—C—C torsion angle = 79.24 (14)°] which is also syn to the methyl substituent of the tolyl group. In the crystal, supra­molecular layers are formed in the bc plane mediated by C—H...O, C—H...N and C—H...π inter­actions. The tolyl group is disordered over two positions in a 0.852 (3):0.148 (3) ratio.

(E)-2-(2,3-Dimethyl­anilino)-N′-(thio­phen-2-yl­methyl­idene)benzohydrazide

In the title compound, C₂₀H₁₉N₃OS, the central benzene ring makes dihedral angles of 45.36 (9) and 55.33 (9)° with the thio­phene ring and the dimethyl-substituted benzene ring, respectively. The dihedral angle between the thio­phene ring and dimethyl-substituted benzene ring is 83.60 (9)°. The thio­phene ring and the benzene ring are twisted from the mean plane of the C(=O)—N—N=C bridge [maximum deviation = 0.0860 (13) Å], with dihedral angles of 23.86 (9) and 24.77 (8)°, respectively. An intra­molecular N—H...O hydrogen bond generates an S(6) ring. In the crystal, mol­ecules are linked by N—H...O and C—H...O hydrogen bonds to the same acceptor atom, forming sheets lying parallel to the bc plane. The crystal packing also features C—H...π inter­actions.