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In the title compound, C6H10N2O2·H2O, the imidazole ring is essentially planar, with a maximum deviation of 0.012 (2) Å. In the crystal, mol­ecules are connected via N—H...O and O—H...O hydrogen bonds, forming a supra­molecular tape along the a axis.

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In the title quinazolin-4-one derivative, C23H18N2O3, both the benzoate [dihedral angle = 79.99 (6)°] and the 2-tolyl [89.02 (7)°] groups are close to orthogonal to the central fused ring system. Both aryl groups are orientated towards the quinazolin-4-one-bound methyl group. In the crystal, mol­ecules are connected into a three-dimensional architecture by C—H...O, C—H...N and C—H...π inter­actions.

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In the title quinazolin-4-one derivative, C24H20N2O3, both the 4-methyl­benzoate [dihedral angle = 83.90 (9)°] and 2-tolyl [87.88 (9)°] groups are almost orthogonal to the central fused ring system. These aryl groups are oriented towards the quinazolin-4-one-bound methyl group. In the crystal, mol­ecules are connected into a three-dimensional architecture by C—H...O, C—H...π and π–π [ring centroid-to-centroid separation = 3.6458 (13) Å] inter­actions.

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The title mol­ecule, C16H13NO, is twisted, the dihedral angle between the terminal phenyl rings being 68.40 (6)°. In the crystal, C—H...O and C—H...N inter­actions lead to supra­molecular layers in the bc plane.

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The title mol­ecule, C17H15NO2, is twisted, the dihedral angle between the terminal benzene rings being 63.30 (6)°. In the crystal, C—H...O and C—H...N inter­actions lead to supra­molecular layers in the ab plane. These are connected along the c axis via C—H...π inter­actions.

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In the title compound, C21H16N2O3S, the central quinazolin-4-one ring is planar (r.m.s. deviation = 0.037 Å). The N-bound benzene and thio­phenyl rings are almost perpendicular to the central plane [dihedral angles = 82.22 (5) and 77.05 (13)°, respectively]. Mol­ecules are connected into a three-dimensional array by C—H...O inter­actions involving both carbonyl O atoms. The thio­phene ring is disordered over two positions, which are approximately parallel and oppositely orientated. The major component refined to a site-occupancy factor of 0.6555 (17).

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The title mol­ecule, C22H17BrN2O4S, has a twisted U shape, the dihedral angle between the quinazolin-4-one and bromo­benzene ring systems being 46.25 (8)°. In order to avoid steric clashes with adjacent substituents on the quinazolin-4-one ring, the N-bound tolyl group occupies an orthogonal position [dihedral angle = 89.59 (8)°]. In the crystal, mol­ecules are connected into a three-dimensional architecture by C—H...O inter­actions, with the ketone O atom accepting two such bonds and a sulfonate O atom one.

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The title compound, C15H12N2OS, exists as the thione tautomer in the solid state. The phenyl group is almost perpendicular [dihedral angle = 87.96 (5)°] to the fused ring system (r.m.s. deviation = 0.036 Å for 13 ring and exocyclic non-H atoms). In the crystal, centrosymmetric dimers, sustained by pairs of N—H...S hydrogen bonds, are connected into layers parallel to (-101) by C—H...O and C—H...S inter­actions.

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In the title methaqua­lone analogue, C16H13N3O3, the 2-tolyl group is almost orthogonal [dihedral angle = 85.20 (5)°] to the fused ring system (r.m.s. deviation of fitted non-H atoms = 0.029 Å). In the crystal, twofold symmetry generates two-mol­ecule aggregates linked by C—H...O and π–π inter­actions [ring centroid–centroid distance = 3.4967 (6) Å].

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In the title methaqua­lone analogue, C23H20N2O2, the planes of the terminal aromatic rings [dihedral angle between them = 64.52 (7)°] approximately face the fused-ring methyl group and both are twisted with respect to the pyrimidine plane (r.m.s. deviation = 0.028 Å), forming dihedral angles of 86.9 (3) (with the 2-tolyl ring) and 65.57 (7)°. The 2-tolyl residue is disordered over two almost coplanar but opposite orientations with the major component having a site-occupancy factor of 0.893 (3). The three-dimensional crystal packing is consolidated by C—H...O, C—H...π and π–π [2-tol­yl–2-tolyl centroid–centroid distance = 3.8099 (6) Å] inter­actions.

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In the title compound, C26H20N2O4, the central isoindole core is almost planar (r.m.s. deviation = 0.043 Å). The phenyl rings lie to either side of the plane [dihedral angles = 88.64 (5) and 67.74 (6)°] and the dihedral angle between the phenyl rings is 63.39 (7)°. In the crystal, mol­ecules are linked by C—H...O inter­actions; notably, one carbonyl O atom accepts three such bonds.

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The five-membered ring in the title imidazolidinone derivative, C11H12N2O2S, adopts an envelope conformation with the S-bound C atom being the flap atom. Overall, the mol­ecule has a U-shaped conformation as both rings are folded towards each other [dihedral angle = 31.66 (6)°]. An eight-membered amide {...HNCO}2 synthon leads to hydrogen-bonded dimeric aggregates in the crystal: these are additionally linked by C—H...π inter­actions.

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In the mol­ecule of the title thio­ester, C14H12O2S, the dihedral angle between the phenyl and benzene rings is 71.8 (3)°. The meth­oxy group is essentially coplanar with the benezene ring to which it is bonded, with an r.m.s. deviation of 0.0065 (5) Å for the non-H atoms involved. In the crystal, weak C—H...π inter­actions are present.

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In the title compound, C14H20N2O2S, the sulfonamide O atoms lie to one side of the benzene ring and the amino­bicyclo­hepta­nyl to the other side [Car—S—N—C torsion angle = −57.93 (11)°; ar = aromatic]. An intra­molecular N—H...N hydrogen bond is formed. In the crystal, a supra­molecular chain is formed along the b axis via N—H...O and N—H...N hydrogen bonds.

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In the title compound, C23H17ClN2O3, the quinazoline fused-ring system, including the ring-bound carbonyl-O and methyl-C atoms, is close to being planar (r.m.s. deviation = 0.044 Å) and is essentially orthogonal to both the 2-tolyl ring [dihedral angle = 89.51 (8)°] and to the ester group [the C—O—C—C torsion angle = −103.69 (16)°]. The carboxyl­ate group is almost coplanar with the benzene ring to which it is attached [O—C—C—C torsion angle = −4.7 (2)°]. The 2-tolyl ring system is disordered over two orientations in a 0.871 (3):0.129 (3) ratio. In the crystal, mol­ecules are consolidated into a three-dimensional architecture by C—H...Cl, C—H...O, C—H...N, C—H...π and π–π inter­actions [inter-centroid distances = 3.6443 (9) and 3.8557 (11) Å].

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In the title compound, C26H21N3O3S, the quinazolinyl group is essentially planar [r.m.s. deviation for the 10 non-H atoms = 0.057 Å]. The isoindoline-1,3-dione group is linked by an SCH2CH2 chain to the pyrimidinyl C atom that lies between the two N atoms. Also, the phenyl group is linked by a CH2CH2 chain at the N atom adjacent to the carbonyl group. This results in a conformation with these substituents lying to either side of the central quinazolinyl unit, with the former being approximately parallel [dihedral angle = 4.93 (7)°], and the phenyl group being inclined [dihedral angle = 71.61 (9)°] to the central quinazolinyl fused-ring system. In the crystal, mol­ecules are consolidated into a three-dimensional architecture by C—H...O inter­actions, involving all three carbonyl-O atoms, and π–π inter­actions occurring between the pyrimidinyl and isoindole-benzene rings [inter-centroid distance = 3.5330 (13) Å].

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Two independent mol­ecules (A and B) comprises the asymmetric unit of the title ester, C17H20OS. The phenyl ring is inclined with respect to the thio­carboxyl group, forming dihedral angles of 58.95 (6) (in mol­ecule A) and 62.28 (6)° (in mol­ecule B). In each independent mol­ecule, one adamantyl methyl­ene C atom is nearly coplanar with the thio­carboxyl group. The major difference between mol­ecules A and B relates to the relationship between the S atom and the coplanar adamantyl methyl­ene C atom [Ca—Cq—Cc—S torsion angles = 178.25 (8) and 6.81 (13)°, respectively; Ca = adamantyl methyl­ene C atom, Cq = quaternary C atom and Cc = carbonyl C atom], whereby the S atom in mol­ecule A has an anti relationship with the methyl­ene C atom and in mol­ecule B, the S atom is syn. In the crystal, C—H...π inter­actions are formed leading to supra­molecular layers in the ac plane.

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In the title compound, C18H15N3O2, the fused ring system is almost planar [the dihedral angle between the six-membered rings is 1.81 (6)°]. The 2-tolyl ring is approximately orthogonal to this plane [dihedral angle = 83.03 (7)°] as is the acetonitrile group [C—O—C—C torsion angle = 79.24 (14)°] which is also syn to the methyl substituent of the tolyl group. In the crystal, supra­molecular layers are formed in the bc plane mediated by C—H...O, C—H...N and C—H...π inter­actions. The tolyl group is disordered over two positions in a 0.852 (3):0.148 (3) ratio.

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In the title compound, C10H7N3OS2, the 16 non-H atoms are almost planar (r.m.s. deviation = 0.037 Å) and the S-bound methyl group is syn to the ketone O atom. In the crystal, centrosymmetrically related mol­ecules are connected by pairs of C—H...O inter­actions between the ketone O and methyl H atoms. The dimeric aggregates are connected into a linear supra­molecular chain along the b axis via π–π inter­actions occurring between the five-membered and benzene rings [centroid–centroid distance = 3.6123 (9) Å]. The chains assemble into layers in the bc plane via S...S inter­actions involving the endocyclic S atoms [S...S = 3.4607 (6) and 3.4792 (6) Å].

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In the title compound, C16H15NO, the dihedral angle between the outer benzene rings is 51.88 (6)°, and each of the central six-membered rings has a boat conformation. The hy­droxy and amino groups are syn, and the hy­droxy H atom forms an intra­molecular O—H...N hydrogen bond. In the crystal, mol­ecules assemble via C—H...O and C—H...π inter­actions, consolidating a three-dimensional architecture.
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