Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Acta Cryst. (2014). F70, 294-298
https://doi.org/10.1107/S2053230X14002118

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Structure of Aurora B-INCENP in complex with barasertib reveals a potential transinhibitory mechanism

F. Sessa and F. Villa

Two structures of Aurora B kinase bound to the specific inhibitor barasertib and to a nonhydrolyzable nucleotide provide evidences for a potential transinhibitory mechanism.

Keywords: Aurora kinases; barasertib; cancer; PKA; small-molecule inhibitors.

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