pH-tuneable binding of 2'-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study

A. Ciulli, C. M. C. Lobley, K. L. Tuck, A. G. Smith, T. L. Blundell and C. Abell

A combined crystallographic, calorimetric and mutagenic study has been used to show how changes in pH give rise to two distinct binding modes of 2'-phospho-ADP-ribose to ketopantoate reductase.

Keywords: binding modes; calorimetry; fragment-based drug design; ketopantoate reductase; site-directed mutagenesis.

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