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The water-coordinated Ni2+ cation in the title compound, [Ni(C10H5N3O4)(H2O)]n, assumes an octa­hedral NiN3O3 coord­ination mode and is N,O-chelated by two deprotonated 2-(pyridin-4-yl)-1H-imidazole-4,5-dicarb­oxy­lic acid (HPyImDC2−) ligands, forming a layer structure extending in the bc plane. The chains are arranged along the b-axis direction, forming a layer structure extending in the bc plane. O—H...O hydrogen bonding between the layers results in the formation of a three-dimensional supra­molecular framework. The structure is isotypic with the Zn analogue [Li et al. (2009). Cryst. Growth Des. 6, 3423–3431].
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