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The title compound, C33H32ClNO4, prepared by methyl­ation of 12-chloro-2,10-dibenz­yl­oxy-9-hydroxy-3-methoxy­tetra­hydro­protoberberine with diazo­methane, contains a fused four-ring system in which the trans-fused rings both have half-chair conformations. No significant inter­molecular inter­actions are observed in the structure.
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