4-(9-Acridin-9-yl­amino)-2,2,6,6-tetra­methyl­piperidine N-oxide

The title compound, C₂₂H₂₆N₃O, crystallizes in space group P2₁ with two mol­ecules in the asymmetric unit. Intermolecular N—H...O hydrogen bonds play an important role in the formation of polymeric chains running along the crystallographic a axis.

3-[(2R*,3S*)-3-(4-Chloro­phenyl)-3-(2-methoxy­anilino)-2-methyl­propionyl]­spiro­[2H-1,3-benzoxazine-2,1′-cyclo­hexan]-4(3H)-one

The title compound, C₃₀H₃₁ClN₂O₄, crystallizes as discrete mol­ecules. Non-classical C—H...O hydrogen bonds link the mol­ecules in the crystal structure into a sheet parallel to (01).

3-[(2R*,3S*)-3-(2-Methoxy­anilino)-2-methyl-3-phenyl­propionyl]­spiro­[2H-1,3-benzoxazine-2,1′-cyclo­hexan]-4(3H)-one

The racemic title compound, C₃₀H₃₂N₂O₄, was synthesized from spiro­[2H-1,3-benzoxazine-2,1′-cyclo­hexan]-4(3H)-one and N-benzyl­idene-2-methoxy­benzen­amine under classical Reformatsky reaction conditions. Intermolecular N—H...O and C—H...O hydrogen bonds link the mol­ecules in the crystal structure into infinite chains along the a axis. These chains form layers parallel to the (001) plane, which are stabilized by weak interlayer C—H...O hydrogen bonds.

(1R,2S,5R)-2-Iso­propyl-5-methyl­cyclo­hexyl (2S,3S)-3-phenyl­oxirane-2-carboxyl­ate

The title compound, C₁₉H₂₆O₃, was synthesized from (1R,2S,5R)-2-iso­propyl-5-methyl­cyclo­hexyl chloro­acetate and benz­aldehyde via the well known Darzen reaction. The absolute configuration was determined from the synthetic precursor. Non-classical C—H...O hydrogen bonds link the mol­ecules in the crystal structure into a sheet parallel to (001).

(5α,8α,9β,11S)-5,7,8,9-Tetra­hydro-11-(fluoro­meth­yl)-9-(3,4,5-trimethoxy­phen­yl)-5,8-methano-1,3-dioxolo[4,5-h][2]benzoxepin

The title compound, C₂₂H₂₃FO₆, is an unexpected product of the fluorination of podophyllol. The absolute configuration was determined from the known configuration of the synthetic precursor. Non-classical C—H...O hydrogen bonds link the mol­ecules in the crystal structure into sheets parallel to (001).

(5R,5aR,8aR,9S)-5-(3,4-di­hydroxy-5-methoxy­phenyl)-9-fluoro-5,8,8a,9-tetra­hydrofuro­[3′,4′:6,7]­naphtho­[2,3-d]-1,3-dioxol-6(5aH)-one acetone solvate

The title compound, C₂₀H₁₇FO₇·C₃H₆O, is a potential antitumour agent. Its absolute configuration was assigned based on that of the synthetic precursor. Intermolecular O—H...O hydrogen bonds link the mol­ecules in the crystal structure into layers parallel to (010). These layers are stabilized by weak interlayer C—H...O hydrogen bonds.

3-(2-Bromo­butano­yl)spiro­[2H-1,3-benzoxazine-2,1′-cyclo­hexan]-4(3H)-one

In the title compound, C₁₇H₂₀BrNO₃, synthesized from spiro­[2H-1,3-benzoxazine-2,1′-cyclo­hexan]-4(3H)-one and 2-bromo­butanoyl bromide, the chair cyclohexane ring in the mol­ecule shows high asymmetric induction in the synthesis of trans β-lactams.

7-(Benz­yloxy)spiro­[2H-1,3-benzoxazine-2,1′-cyclo­hexa­n]-4(3H)-one

In the title compound, C₂₀H₂₁NO₃, the dihedral angle between the two benzene rings is 8.79 (7)° and the cyclo­hexane ring adopts a chair conformation. The mol­ecules are linked by paired N—H...O hydrogen bonds into centrosymmetric R₂²(8) dimers.