N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-di­hydro-1H-pyrazol-4-yl)-2-(4-nitro­phen­yl)acetamide

In the title compound, C₁₉H₁₈N₄O₄, the nitro­phenyl and phenyl rings are twisted by 67.0 (6) and 37.4 (4)°, respectively, with respect to the pyrazole ring plane [maximum deviation = 0.0042 (16) Å]. The dihedral angle between the mean planes of the phenyl rings is 59.3 (3)°. The amide group, with a C—N—C—C torsion angle of 177.54 (13)°, is twisted away from the plane of the pyrazole ring in an anti­periplanar conformation. In the crystal, N—H...O hydrogen bonds involving the carbonyl group on the pyrazole ring and the amide group, together with weak C—H...O inter­actions forming R₂²(10) graph-set motifs, link the mol­ecules into chains along [100]. Additional weak C—H...O inter­actions involving the nitro­phenyl rings further link the mol­ecules along [001], also forming R₂²(10) graph-set motifs, thereby generating (010) layers.

2-(2-Methyl­phen­yl)-N-(1,3-thia­zol-2-yl)acetamide

In the title compound, C₁₂H₁₂N₂OS, the dihedral angle between the benzene and thia­zole rings is 83.5 (7)°. The acetamide group is almost coplanar with the thia­zole ring, being twisted from it by 4.2 (9)°. In the crystal, pairs of N—H...N hydrogen bonds link mol­ecules into inversion dimers, generating R₂²[8] loops; the dimers are stacked along [001].

4-[(E)-(4-Hy­droxy­benzyl­idene)amino]-3-methyl-1H-1,2,4-triazole-5(4H)-thione

The title compound, C₁₀H₁₀N₄OS, is nearly planar with the mean planes of the hy­droxy­benzyl and triazole rings inclined at an angle of only 3.2 (7)°. In the crystal, O—H...N hydrogen bonds between the hy­droxy group and the triazole ring in concert with weak N—H...S inter­molecular inter­actions between the triazole ring and thione group form chains along [-210] enclosing R₂²(8) graph-set motifs. A weak intra­molecular C—H...S inter­action and inter­molecular π–π inter­actions [centroid–centroid distance = 3.5990 (15) Å] are also observed.

3-(4-Fluoro­benzo­yl)-4-(4-fluoro­phen­yl)-4-hy­droxy-2,6-di­phenyl­cyclo­hexane-1,1-dicarbo­nitrile

In the title compound, C₃₃H₂₄F₂N₂O₂, the cyclo­hexane ring adopts a slightly distorted chair conformation. The dihedral angle between the planes of the phenyl rings is 71.80 (9)°, while the planes of the fluoro­phenyl and fluoro­benzoyl rings are inclined to one another by 31.04 (10)°. The dihedral angles between the planes of the phenyl ring adjacent to the 4-hydroxy group and those of the the fluoro­phenyl and fluoro­benzoyl rings are 51.64 (10) and 34.31 (10)°, respectively, while the corresponding angles for the phenyl ring adjacent to the 3-(4-fluorobenzoyl) group are 57.51 (9) and 85.02 (10)°, respectively. An intra­molecular O—H...O hydrogen bond generates an S(6) ring motif. In the crystal, mol­ecules are linked via pairs of O—H...N hydrogen bonds, forming inversion dimers. The dimers are linked via C—H...N and C—H...O hydrogen bonds, forming chains along the c-axis direction. C—H...F hydrogen bonds link the chains into sheets lying parallel to the bc plane.

4-[(4-Acetyl­phen­yl)amino]-2-methyl­idene-4-oxo­butanoic acid

In the title compound, C₁₃H₁₃NO₄, the N—C(=O) bond length of 1.354 (2) Å is indicative of amide-type resonance. The dihedral angle between the mean planes of the benzene ring and oxo­amine group is 36.4 (3)°, while the mean plane of the 2-methyl­idene group is inclined by 84.2 (01)° from that of the oxo­amine group. In the crystal, classical O—H...O hydrogen bonds formed by the carb­oxy­lic acid groups and weak N—H...O weak inter­actions formed by the amide groups and supported by weak C—H...O inter­actions between the 2-methyl­idene, phenyl and acetyl groups with the carb­oxy­lic acid, oxo­amine and acetyl O atoms, together link the mol­ecules into dimeric chains along [010]. The O—H...O hydrogen bonds form R₂²(8) graph-set motifs.

1-{3-(4-Chloro­phen­yl)-5-[4-(propan-2-yl)phen­yl]-4,5-di­hydro-1H-pyrazol-1-yl}butan-1-one

In the title compound, C₂₂H₂₅ClN₂O, the pyrazole ring exhibits an envelope conformation with the methine C atom as the flap. The benzene rings are twisted by 3.3 (5) and 84.6 (5)° from the pyrazole mean plane, and are inclined to each other by 81.4 (4)°. In the crystal, pairs of weak C—H...O hydrogen bonds form centrosymmetric dimers with an R₂²(16) graph-set motif. C—H...π inter­actions link the dimers into columns propagating in [100].

1-{3-(4-Chloro­phen­yl)-5-[4-(propan-2-yl)phen­yl]-4,5-di­hydro-1H-pyrazol-1-yl}propan-1-one

In the title compound, C₂₁H₂₃ClN₂O, the dihedral angle between the benzene rings is 83.2 (6)°, while the mean plane of the pyrazole ring [r.m.s. deviation = 0.043 (1) Å] makes dihedral angles of 3.4 (3) and 86.2 (1)° with the benzene rings. In the crystal, a pair of weak C—H...O inter­actions between the benzene ring and the propan-1-one group link the mol­ecules into an inversion dimer with an R₂²(16) graph-set motif. In addition, a weak π–π stacking inter­action [centroid–centroid distance = 3.959 (4) Å] connects the dimers into a tape running along [201].

4-[(4-Bromo­phenyl)amino]-2-methyl­idene-4-oxo­butanoic acid

In the title compound, C₁₁H₁₀BrNO₃, two independent mol­ecules (A and B) crystallize in the asymmetric unit. The dihedral angles between the mean planes of the 4-bromo­phenyl ring and amide group are 24.8 (7) in mol­ecule A and 77.1 (6)° in mol­ecule B. The mean plane of the methyl­idene group is further inclined by 75.6 (4) in mol­ecule A and 72.5 (6)° in mol­ecule B from that of the amide group. In the crystal, N—H...O hydrogen bonds formed by amide groups and O—H...O hydrogen bonds formed by carb­oxy­lic acid groups are observed and supported additionally by weak C—H...O inter­actions between the methyl­idene and amide groups. Together, these link the mol­ecules into chains of dimers along [110] and form R₂²(8) graph-set motifs.

1-{3-(4-Chloro­phen­yl)-5-[4-(propan-2-yl)phen­yl]-4,5-di­hydro-1H-pyrazol-1-yl}ethanone

In the title compound, C₂₀H₂₁ClN₂O, the dihedral angles between the pyrazole ring (r.m.s. deviation = 0.049 Å) and the benzene and chloro­benzene rings are 84.65 (10) and 3.35 (10)°, respectively. In the crystal, inversion dimers linked by pairs of weak C—H...O inter­actions generate R₂²(16) loops. Weak π–π stacking inter­actions [centroid–centroid distance = 3.8490 (11) Å] are also observed.

(2E)-1-(4-Chloro­phen­yl)-3-[4-(propan-2-yl)phen­yl]prop-2-en-1-one

In the title compound, C₁₈H₁₇ClO, the dihedral angle between the benzene rings is 53.5 (1)°. The mean plane of the prop-2-en-1-one group is twisted by 24.5 (8) and 33.5 (3)° from the chloro- and propanyl-substituted rings, respectively.