tert-Butyl 4-{[2-amino-4-(2-hy­droxy­phen­yl)pyrimidin-5-yl]meth­yl}piperazine-1-carboxyl­ate

In the title compound, C₂₀H₂₇N₅O₃, the central piperazine ring adopts a chair conformation, with the N-bound carboxyl­ate and methyl­ene substituents occupying bis­ectional and equatorial orientations, respectively. A twist is evident between the aromatic rings [dihedral angle = 25.61 (9)°] but an intra­molecular O—H...N hydrogen bond persists between these. Supra­molecular tapes along [1-10] are formed in the crystal packing through N(amino)—H...O(hydrox­yl) and N(amino)—H...N(pyrimidin­yl) hydrogen bonds, and these are linked into layers in the ab plane by π–π inter­actions [inter-centroid distance between pyrimidinyl rings = 3.5919 (9) Å].