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In the title compound, C18H18N4O4S2, the mean planes passing through the tosyl benzene rings form dihedral angles of 48.42 (9) and 15.1 (1)° with the amino­pyrimidine ring. In the crystal, mol­ecules associate via N—H...N and N—H...O hydrogen bonds, forming extended hydrogen-bonded sheets that lie parallel to the bc plane. The N—H...N hydrogen bonds propagate along the b-axis direction, while the N—H...O hydrogen bonds propagate along the c-axis direction.
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