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Current data deposited in the Protein Data Bank have been used to guide the design of a modular 96-well crystallization screen (HELIX) that integrates into one format cryofreezing, additives to stabilize specific topologies, formulations for higher molecular weight targets and a customizable orthogonal-based screen. Moreover, contrary to most current commercial nucleic acid crystallization kits, the formulations in HELIX avoid cacodylate-containing buffers, which can mask the scattering of useful intrinsic anomalous scatterers, such as bromine and selenium.
