The structure of S100A12 in a hexameric form and its proposed role in receptor signalling

O. V. Moroz, A. A. Antson, E. J. Dodson, H. J. Burrell, S. J. Grist, R. M. Lloyd, N. J. Maitland, G. G. Dodson, K. S. Wilson, E. Lukanidin and I. B. Bronstein

The structure of a hexameric form of S100A12, a member of the S100 family of proteins, has been solved at 2.7 Å resolution. The results suggest a functional significance for the hexamer.

Keywords: S100 protein; calcium signalling; RAGE; receptor oligomerization.

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