5′′-(4-Nitro­benzyl­idene)-7′-(4-nitro­phen­yl)-1′′-methyl-1′,3′,5′,6′,7′,7a′-hexa­hydro­dispiro­[ace­naphthyl­ene-1,5′-pyrrolo­[1,2-c][1,3]thia­zole-6′,3′′-piperidine]-2,4′′(1H)-dione including an unknown solvate

The title compound, C₃₅H₂₈N₄O₆S, crystallizes with two mol­ecules in the asymmetric unit. In both mol­ecules, the piperidine ring adopts a shallow-chair conformation, the thia­zole ring adopts a twisted conformation about the C_m—N bond (m = methine) and the pyrrole ring adopts an envelope conformation with the C atom shared with the thia­zole ring as the flap. In the crystal, inversion dimers linked by pairs of C—H...O inter­actions generate R₂²(34) loops for one of the asymmetric mol­ecules. Further C—H...O links also involving the other mol­ecule lead to a three-dimesional network. The contribution of the highly disordered solvent to the scattering was removed with SQUEEZE option of PLATON [Spek (2009). Acta Cryst. D65, 148–155]. The solvent contribution is not included in the reported mol­ecular weight and density.

5′′-(2-Fluoro­benzyl­idene)-1′-(2-fluoro­phen­yl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a'-octa­hydro­dispiro­[ace­naphthyl­ene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1H)-dione

In the title compound, C₃₇H₃₂F₂N₂O₂, the central six-membered piperidine ring adopts a twisted half-chair conformation, with the N and methyl­ene C atoms deviating by −0.2875 (16) and 0.4965 (15) Å, respectively, from the mean plane defined by the other four atoms. The piperidine connected to the octa­hydro­indolizine ring is in a half-chair conformation. The five-membered pyrrole ring adopts a slightly twisted envelope conformation with the piperidine C atom as the flap atom. The F and H atoms of both fluoro­benzene rings are disordered, with occupancy factors of 0.941 (3):0.059 (3) and 0.863 (3):0.137 (3). The mol­ecular structure features some intra­molecular C—H...O inter­actions. In the crystal, a supra­molecular zigzag chain sustained by C—H...F inter­actions parallel to the c axis is formed, generating a C(12) graph-set motif.

1′′-Allyl-5′′-(4-meth­oxy­benzyl­idene)-7′-(4-methoxy­phen­yl)-1′,3′,5′,6′,7′,7a′-hexa­hydro­dispiro­[ace­naphthyl­ene-1,5′-pyrrolo­[1,2-c][1,3]thia­zole-6′,3′′-piperidine]-2,4′′(1H)-dione

In the title compound, C₃₉H₃₆N₂O₄S, the piperidine ring adopts a twisted half-chair conformation. In the pyrrolo­thia­zole fused-ring system, the pyrrole ring adopts an envelope conformation (with the C atom bound to the thia­zole ring being the flap atom) and the thia­zole ring also exhibits an envelope conformation (with the N atom bound to the pyrrole ring as the flap). The mol­ecular structure features a weak intra­molecular C—H...O inter­action. In the crystal, a C—H...O inter­action forms a linear chain along the diagonal of the ac plane, generating a C(14) graph-set motif. A weak C—H...π inter­action also occurs.