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With respect to the triazole ring in the title compound, C19H16FN3O, the p-tolyl ring is inclined [dihedral angle = 51.79 (11)°], whereas the chalcone residue is almost coplanar [O—C—C—N and C—C—C—C torsion angles = −178.71 (19) and 178.42 (18)°, respectively]. The conformation about the C=C bond [1.328 (3) Å] is E, and the triazole methyl group and the carbonyl O atom are syn. In the crystal, centrosymmetrically related mol­ecules are connected by π–π inter­actions between the triazole and p-tolyl rings [centroid–centroid distance = 3.6599 (12) Å] and these are linked into a three-dimensional architecture by C—H...N and C—H...π inter­actions.

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Two independent mol­ecules comprise the asymmetric unit of the title compound, C24H26N4O. The major difference between them is found in the relative orientation of the triazole-bound p-tolyl group which have the opposite sense of twist [N—N—C—C torsion angles = 55.8 (3) and −49.8 (3)°]. The chalcone residue is almost coplanar with the triazole ring [N—C—C—O and C—C—C—C torsion angles = −178.9 (2) and −178.5 (2)°, respectively; cf. 177.9 (3) and 168.5 (3)°, respectively, in the second mol­ecule]. The conformation about each C=C double bond is E and in each case the triazole methyl group is syn to the carbonyl O atom. In the crystal, mol­ecules aggregate into layers parallel to (-113). The first independent mol­ecule self-associates into a layer via C—H...O and C—H...π inter­actions. By contrast, layers comprising the second independent mol­ecule do not feature specific inter­actions between mol­ecules. The global crystal packing comprises alternating layers.

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In the title compound, C13H19N3S, the methyl­amine substituent is coplanar with the thia­diazole ring to which it is attached [C—N—C—S torsion angle = 175.9 (2)°] and the amine H atom is syn to the thia­diazole S atom. Supra­molecular chains along [101], sustained by N—H...N hydrogen bonding, feature in the crystal packing.

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In the title compound, C17H18N4OS2, the 2-thienyl ring is disordered over two co-planar, opposite orientations in a 0.684 (2): 0.316 ratio. The 1,3,4-oxa­diazole ring is almost co-planar with the attached 2-thienyl ring [dihedral angles of 5.34 (19) and 4.8 (5)° for the major and minor components, respectively]. The relative disposition of the thione- and ring-S atoms is anti for the major orientation of the 2-thienyl residue. Overall, the shape of the mol­ecule approximates the letter V. In the crystal, a three-dimensional architecture is consolidated by a combination of weak C—H...S and C—H...π contacts.

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In the title compound, C26H34F2N6S, the triazole ring is linked to a benzene ring via an imine bond [N=C = 1.255 (2) Å; conformation: E], with a dihedral angle of 25.21 (11)° between the rings. The 4-ethyl­piperazinyl residue is folded away from the thione-S atom. In the crystal, helical supra­molecular chains propagating along [010] and sustained by weak C—S...π(triazole) inter­actions occur [S...centroid distance = 3.2872 (10) Å]. Links between these chains are of the type benzene-C—H...N(imine) and π–π [between centrosymmetrically related benzene rings with an inter-centroid distance of 3.9241 (15) Å] and result in a three-dimensional architecture.

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In the title compound, C25H32F3N5S, two independent mol­ecules comprise the asymmetric unit and are related across a pseudo-centre of inversion. The piperazine rings have chair conformations with each N-bound substituent occupying an equatorial position so that the dihedral angles between the planes of the triazole and benzene ring are 78.20 (19) and 79.10 (19)° for the two independent mol­ecules, indicating that the mol­ecules have an L-shape. In the crystal, a three-dimensional architecture is stabilized by C—H...π inter­actions. The crystal studied was an inversion twin with the fractional contribution of the minor component being 0.27 (9).

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In the title compound, C13H11N3S2, the triazole and thio­phene rings are coplanar [dihedral angle = 6.22 (13)°]. By contrast, the phenyl ring is perpendicular to the triazole ring [dihedral angle = 85.58 (13)°], so that the mol­ecule has an L-shape. The thio­phene S atom is syn with the ring imine N atom. In the crystal, eight-membered {...HNCS}2 synthons form between centrosymmetrically related mol­ecules, leading to dimeric aggregates that are connected into a supra­molecular layer parallel to (101) by π–π inter­actions between centrosymmetrically related triazole rings [centroid–centroid distance = 3.6091 (15) Å] and C—H...π inter­actions.

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In the title compound, C19H23N3OS, the oxa­diazole and benzene rings are inclined at a dihedral angle of 50.30 (11)°, with the major twist between them occurring at the ring–methyl­ene N—C bond [N—N—C—N torsion angle = −101.2 (2)°]. In the crystal, helical supra­molecular chains along [010] are sustained by N—H...S hydrogen bonds. These are linked into layers lying parallel to (-101) by methyl­ene–phenyl C—H...π inter­actions.

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In the title compound, C19H22FN3OS, the dihedral angle between the inclined oxa­diazole and benzene rings is 52.7 (3)°. In the crystal, helical supra­molecular chains along [100] are sustained by N—H...S hydrogen bonds supported by methyl­ene–benzene C—H...π inter­actions. The crystal studied was an inversion twin with the fractional contribution of the minor component being 0.33 (14).

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In the title compound, C24H17BrFN3S, the pyrazole ring is almost planar (r.m.s. deviation = 0.043 Å), with all but the perpendicular fluoro­benzene ring substituents [dihedral angle = 77.9 (3)°] being very approximately coplanar [dihedral angle with the 2-thienyl ring = 19.4 (3)° and with the bromo­benzene ring = 20.3 (3)°; dihedral angle between the 2-thienyl and attached phenyl ring = 11.0 (4)°], so that the mol­ecule has a T-shape. In the crystal, supra­molecular chains along the b-axis direction are sustained by C—H...S and C—Br...π inter­actions.

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In the title compound, C17H15N3O2, two independent mol­ecules (A and B) comprise the asymmetric unit. The major conformational difference arises in the relative orientation of the pyrazole ring amine and dioxole substituents which are anti in A and syn in B. The five-membered dioxole ring in each mol­ecule has an envelope conformation with the methyl­ene C atom as the flap. The mean plane through the benzodioxole and benzene groups make dihedral angles of 31.67 (8) and 68.22 (9)°, respectively, with the pyrazole ring in A; the equivalent values for B are 47.18 (7) and 49.08 (9)°. In the crystal, supra­molecular zigzag chains along the b-axis direction arise as a result of N—H...N hydrogen bonding. These are consolidated into supra­molecular double chains via C—H...O and C—H...π inter­actions.
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