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The asymmetric unit of the title compound, C21H22N4O4S, contains two mol­ecules (A and B), in which the thia­zine rings adopt an S-envelope conformation with the S atoms displaced by 0.621 (2) and 0.697 (2) Å from the mean planes formed by the remaining ring atoms. The dihedral angles between the N-methyl­acetamide groups and the meth­oxy­benzene rings are 8.67 (10) and 54.49 (6)° in the two mol­ecules and the equivalent torsion angles in the N-methyl­acetamide chains connecting the ring systems also differ. In the crystal, N—H...O hydrogen bonds connect the components into C(4) [100] chains of alternating A and B mol­ecules. The packing is consolidated by weak C—H...O inter­actions, which generate a three-dimensional network.
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