Acta Crystallographica Section F
Acta Crystallographica
Section F
STRUCTURAL BIOLOGY COMMUNICATIONS
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Acta Cryst.
(2012).
F
68
,
1013-1017
https://doi.org/10.1107/S1744309112031570
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The role of active-site Phe87 in modulating the organic co-solvent tolerance of cytochrome P450 BM3 monooxygenase
J. Kuper
,
K. L. Tee
,
M. Wilmanns
,
D. Roccatano
,
U. Schwaneberg
and
T. S. Wong
Active-site Phe87 of cytochrome P450 BM3 protects the haem from DMSO molecule, thereby conferring higher organic co-solvent tolerance.
Keywords:
cytochrome P450 BM3
;
CYP102A1
;
organic co-solvent tolerance
;
directed evolution
;
DMSO
.
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