(S)-4-Phenyl-2-(1,2,3,4-tetra­hydro­isoquinolin-3-yl)-1,3-thia­zole

In the title compound, C₁₈H₁₆N₂S, the N-containing ring adopts a half-chair configuration. The crystal packing features C—H...N contacts. There is no π–π stacking within the crystal structure.

(S)-Methyl 2-benzamido-3-(3,4-dimeth­oxy­phen­yl)propano­ate

The dimethoxypbenzene ring in the title compound, C₁₉H₂₁NO₅, is gauche to the amide group and anti to the ester group. The chirality was confirmed to be S from two-dimensional NMR spectroscopy. In the crystal, N—H...O and C—H...O hydrogen bonds and several short-contact inter­actions (2.07–3.45 Å) create chains parallel to [110]. The phenyl ring is disordered over two orientations in a 0.54 (2):0.46 (2) ratio.

(S)-Benzyl 3-phenyl­carbamoyl-1,2,3,4-tetra­hydro­isoquinoline-2-carboxyl­ate

There are two independent mol­ecules in the asymmetric unit of the title compound, C₂₄H₂₂N₂O₃. The heterocyclic ring assumes a twisted boat conformation and N—H...O inter­actions help to construct the three-dimensional network within the crystal packing.

Ethyl 2-(3,5-dimethyl-1,1-dioxo-2H-1λ⁶,2,6-thia­diazin-4-yl)benzoate

In the title compound, C₁₄H₁₆N₂O₄S, the thia­diazine ring is in a half-boat conformation. The aromatic ring deviates from the plane of this moiety at an angle of 74.6 (2)°. The structure displays inter­molecular N—H...O hydrogen bonding [N...O = 2.8157 (16) Å], creating ribbons along the [010] axis. There are also weak C—H...O inter­actions in the crystal but no π–π stacking.

(S)-4-tert-Butyl-2-(1,2,3,4-tetra­hydro­isoquinolin-3-yl)-1,3-thia­zole

In the title compound, C₁₆H₂₀N₂S, a potential tetra­hydro­isoquinoline (TIQ) thia­zole ligand, the N-containing six-membered ring of the TIQ unit adopts a half-chair conformation. There are four mol­ecules in the asymmetric unit. No classical hydrogen bonds or π–π inter­actions were found in the crystal structure.

2-(3,5-Dimethyl-1,1-dioxo-2H-1λ⁶,2,6-thia­diazin-4-yl)benzoic acid

In the title mol­ecule, C₁₂H₁₂N₂O₄S, the S atom of the thia­diazine ring deviates by 0.5104 (4) Å from the mean plane of the other five atoms [largest deviation = 0.0623 (15) Å] giving a slightly distorted sofa conformation. The carb­oxy H atom was refined as disordered over two sets of sites with refined occupancies of 0.58 (2) and 0.48 (2). This corresponds to rotational disorder of the C=O and O—H groups about the attached C—C bond. In the crystal, O—H...O and N—H...O hydrogen bonds connect the mol­ecules into chains along [110].

(2-(Benzo[d]thia­zol-2yl-meth­oxy)-5-chloro­phen­yl)(phen­yl)methanone

In the title compound, C₂₁H₁₄ClNO₂S, the dihedral angle between the benzothia­zole and diphenyl methanone groups is 68.6 (2)°. The crystal structure consists of dimeric units generated by C—H...N bonds, further linked by C—H...O bonds and C—H...π and π–π inter­actions [centroid–centroiddistance = 3.856 (2) Å], which lead to a criss-cross assembly parallel to (001).

Methyl 2-(2,3,5-trimethyl-1,1-dioxo-2H-1λ⁶,2,6-thia­diazin-4-yl)benzoate

There are two mol­ecules, A and B, in the asymmetric unit of the title compound, C₁₄H₁₆N₂O₄S, which is the first example reported in this family of compounds in which the Nsp³ atom of the thia­diazine ring is methyl­ated. The thia­diazine rings adopt shallow envelope conformations, with the S atoms displaced by 0.319 (12) and 0.182 (12) Å from the mean planes of the other ring atoms in mol­ecules A and B, respectively. The dihedral angles between the thia­diazine mean planes (excluding S) and the attached benzene rings are 86.8 (3) and 86.7 (3)° for mol­ecules A and B, respectively.