Structural and biophysical analysis of interactions between cod and human uracil-DNA N-glycosylase (UNG) and UNG inhibitor (Ugi)

N. G. Assefa, L. Niiranen, K. A. Johnson, H.-K. S. Leiros, A. O. Smalås, N. P. Willassen and E. Moe

A structural and biophysical study of the interactions between cod and human uracil-DNA N-glycosylase (UNG) and their inhibitor Ugi is presented. The stronger interaction between cod UNG and Ugi can be explained by a greater positive electrostatic surface potential.

Keywords: cold adaptation; uracil-DNA N-glycosylase; Atlantic cod; protein-inhibitor complex; protein-protein interactions; isothermal titration calorimetry; binding affinity.

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