Fluconazole–malonic acid (1/1)

Co-crystallizaton of the anti­fungal drug fluconazole [2-(2,4-difluoro­phen­yl)-1,3-bis­(1H-1,2,4-triazol-1-yl)propan-2-ol] with malonic acid in acetonitrile solution resulted in the formation of the title 1:1 co-crystal, C₁₃H₁₂F₂N₆O·C₃H₄O₄. The geometry around the central fluconazole atom is distorted tetrahedral. The dihedral angles between the triazole rings and the fluorinated phenyl ring are 30.64 (7) and 61.91 (5)°. In the crystal, the basic packing motif may be envisioned as a cyclic aggregate formed of two fluconazole mol­ecules linked by two malonic acid mol­ecules through O—H...N and O—H...O hydrogen bonds. Such aggregates are further connected into (001) layers by further O—H...N hydrogen bonds. The structure also features weak non-classical C—H...O and C—H...N inter­actions.