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In the title compound, C14H16N6O6·C2H6O·H2O, both substit­uents of the benzene ring are approximately planar with maximum deviations from the mean plane of 0.0561 (12) (an imine N atom) and 0.1419 (11) Å (a meth­oxy O atom). The substituents are tilted out of the plane of the benzene ring by 64.48 (4) and 70.08 (5)°, respectively. In the crystal, mol­ecules form centrosymmetric dimers associated via pairs of N—H...O hydrogen bonds. The dimers are linked via the water and ethanol mol­ecules, forming two-dimensional hydrogen-bond networks lying parallel to (100).
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