Structure of the mexicain–E-64 complex and comparison with other cysteine proteases of the papain family

A comparison of the binding site of mexicain for E-64 with those of other E-64–cysteine protease complexes shows that highly conserved interactions are replaced by other interactions in which water molecules play an essential role.

Crystallization by capillary counter-diffusion and structure determination of the N114A mutant of the SH3 domain of Abl tyrosine kinase complexed with a high-affinity peptide ligand

The crystallographic structure of the N114A mutant of the SH3 domain of the Abelson leukaemia virus tyrosine kinase complexed with a high-affinity peptide is reported. An X-ray diffraction data set was collected directly from crystals from the initial screening using the capillary counter-diffusion technique.