Telaprevir: helical chains based on three-point hydrogen-bond connections

The crystal structure of the title compound [systematic name: (1S,3aR,6aS)-2-((2S)-2-{[(2S)-2-cyclo­hexyl-2-(pyrazine-2-car­bonyl­amino)­acet­yl]amino}-3,3-dimethyl­butano­yl)-N-[(3S)-1-(cyclo­propyl­amino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexa­hydro-1H-cyclo­penta­[c]pyrrole-1-carboxamide], C₃₆H₅₃N₇O₆, contains two independent mol­ecules, which possess distinct conformations and a disordered cyclo­penta­[c]pyrrolidine unit. In the crystal, mol­ecules are linked into helical chains via three-point N—H...O hydrogen-bond connections in which three NH and three carbonyl groups per mol­ecule are utilized. The chiralities of the six stereocentres per mol­ecule inferred from this study are in agreement with the synthetic procedure.