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In the title compound, C25H32N4O4, both piperazine rings adopt a chair conformation. One of dioxolane ring systems is essentially planar [dihedral angle = 0.9 (2)°] while the other adopts a slightly disordered envelope conformation, the mean plane of the dioxolane ring being twisted by 3.6 (2)° from that of the benzene ring. The dihedral angle between the benzene rings is 69.9 (5)°. No classical hydrogen bonds were observed.
organic compoundsOpen access
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In the title compound, C15H13F3O2S, the dihedral angle between the benzene rings is 79.5 (1)°. The ester group is twisted by 7.6 (1)° from the mean plane of the adjacent benzene ring. Disorder was modeled over two sites for one F atom of the trifluoromethyl group with an occupancy ratio of 0.54 (6):0.46 (6). In the crystal, molecules are linked via weak C—H
O hydrogen bonds, forming two-dimensional networks lying parallel to (101). The networks are linked via C—Hπ interactions, leading to the formation of a three-dimensional supramolecular structure.
O hydrogen bonds, forming two-dimensional networks lying parallel to (101). The networks are linked via C—Hπ interactions, leading to the formation of a three-dimensional supramolecular structure.organic compoundsOpen access
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In the title compound, C12H16N2O2, the piperazine ring has a chair conformation. The dihedral angle between the mean planes of the benzene ring and the acetyl group is 48.7 (1)°. In the crystal, molecules are linked via O—HO hydrogen bonds, forming chains propagating along [010].
O hydrogen bonds, forming chains propagating along [010].organic compoundsOpen access
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In the title compound, C12H16N4O2, the piperazine ring is in a slightly distorted chair conformation. In the molecule, the mean plane of the nitro group is twisted by 8.0 (3)° from that of the benzene ring. Also, the mean plane of the 2-nitrobenzyl ring is twisted slightly from that of the piperazine ring, with an N—N=C—C torsion angle of −176.24 (11)°. In the crystal, pairs of weak C—HO interactions link the molecules into dimers approximately along [010].
O interactions link the molecules into dimers approximately along [010].organic compoundsOpen access
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In the title compound, C14H9F3O2S, the dihedral angle between the mean planes of the benzene rings is 88.7 (2)°. The carboxylic acid group is twisted by 13.6 (7)° from the mean plane of its attached aromatic ring. One of the F atoms of the trifluoromethyl group is disordered over two sites in a 0.61 (7):0.39 (7) ratio. In the crystal, inversion dimers linked by pairs of O—HO hydrogen bonds generate R22(8) loops. Weak C—HF interactions are also observed.
O hydrogen bonds generate R22(8) loops. Weak C—HF interactions are also observed.organic compoundsOpen access
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In the title compound, C14H18N4, the piperazine ring is in a slightly distorted chair conformation. The indole ring system is twisted from the piperazine ring, making a dihedral angle of 7.27 (11)°. In the crystal, N—HN hydrogen bonds link molecules into chains along [10-1].
N hydrogen bonds link molecules into chains along [10-1].organic compoundsOpen access
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The title compound, C15H12N4O4·2H2O, crystallizes with two independent water molecules in the asymmetric unit. The dihedral angles between the mean planes of the benzene and pyrimidine rings and that of the pyrimidin-4-one ring are 85.1 (9) and 82.1 (1)°, respectively. The mean plane of the pyrimidine ring is twisted by 12.8 (8)° from that of the pyrimidin-4-one ring. The dihedral angles between the benzene ring and the mean planes of the pyrimidine and pyrimidin-4-one rings are 85.1 (9) and 82.1 (1)°, respectively.In the crystal, N–HO, O—HN and O—HO hydrogen bonds involving both water molecules are present; these link the molecules into a two-dimensional network parallel to (010). In addition, weak C—Hπ and π–π [centroid–centroid distance = 3.6183 (8) Å] interactions occur.
O, O—HN and O—HO hydrogen bonds involving both water molecules are present; these link the molecules into a two-dimensional network parallel to (010). In addition, weak C—Hπ and π–π [centroid–centroid distance = 3.6183 (8) Å] interactions occur.
