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The title compound, C21H17N3O5·H2O, exists in the keto form with an E conformation with respect to the azomethine double bond. The twist angles between the aromatic rings are in the range 4.67 (10)–17.54 (10)°. A water mol­ecule of solvation is present in the lattice. A conventional intra­molecular O—H...N hydrogen bond increases the rigidity of the mol­ecule. Inter­molecular O—H...O, N—H...O and C—H...O hydrogen-bonding inter­actions establish a supra­molecular linkage among the mol­ecules in the crystal structure. There are also C—H...π inter­actions present.
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