research papers
The first X-ray structure of p38α cocrystallized with TAK-715 is presented, as well as new high-resolution structures of p38α bound to SB-203580, SCIO-469 and VX-745. The impact of crystallization conditions and selectivity profiles on protein conformation is discussed.
Keywords: p38α; TAK-715; SB-203580; SCIO-469; VX-745; selectivity; soaking; protein kinases; inhibitor design.