The influence of detergents on the solubility of membrane proteins

M. A. Rosenow, C. L. Magee, J. C. Williams and J. P. Allen

The dependence of protein solubility on ionic strength was measured for the bacterial reaction center in different detergents and amphiphiles. The detergent and amphiphile combinations that yielded the highest solubility of the protein are correlated with those that yield protein crystals.

Keywords: integral membrane proteins; detergents; amphiphiles; protein solubility.

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