Acta Crystallographica Section D
Acta Crystallographica
Section D
STRUCTURAL BIOLOGY
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Acta Cryst.
(2011).
D
67
,
707-715
https://doi.org/10.1107/S0907444911023821
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Download citation
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Structural and biochemical characterization of
N
5
-carboxyaminoimidazole ribonucleotide synthetase and
N
5
-carboxyaminoimidazole ribonucleotide mutase from
Staphylococcus aureus
P. Brugarolas
,
E. M. Duguid
,
W. Zhang
,
C. B. Poor
and
C. He
Purine biosynthesis is considered to be a promising new antibiotic target; in this article, the structural and biochemical characterization of
S. aureus
PurK and PurE are described.
Keywords:
purine biosynthesis
;
Staphylococcus aureus
;
enzyme kinetics
;
structure-based drug discovery
;
antimicrobials
.
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