Acta Crystallographica Section D
Acta Crystallographica
Section D
STRUCTURAL BIOLOGY
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Acta Cryst.
(2014).
D
70
,
2765-2774
https://doi.org/10.1107/S1399004714017775
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Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex
L. Záková
,
E. Kletvíková
,
M. Lepsík
,
M. Collinsová
,
C. J. Watson
,
J. P. Turkenburg
,
J. Jirácek
and
A. M. Brzozowski
[AsnB26]- and [GlyB26]-insulin mutants attain a B26-turn like fold without assistance of chemical modifications. Their structures match the insulin receptor interface and expand the spectrum of insulin conformations.
Keywords:
insulin
;
insulin receptor
;
complex
;
active conformation
;
molecular dynamics
;
isothermal titration microcalorimetry
.
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