Half a century of Ramachandran plots

The most relevant aspects of fifty-year history of the Ramachandran plot are summarized, from the original ideas of Gopalasamudram Narayana Ramachandran to subsequent revisions and to applications in structural biology.

Structural and functional characterization of the N-­terminal domain of the yeast Mg²⁺ channel Mrs2

The first structure of the N-terminal domain of the Mg²⁺ channel Mrs2 in a monomeric form and a pentameric model of Mrs2 generated using the prokaryotic homologue CorA are presented. Gating and metal-sensing residues were proposed based on the model and were validated using mutational and functional studies in vivo.