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The statistical effects of translational noncrystallographic symmetry can be characterized by maximizing parameters describing the noncrystallographic symmetry in a likelihood function, thereby unmasking the competing statistical effects of twinning.

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A fast analytical method for calculating mask-based bulk-solvent scale factors and overall anisotropic correction factors is introduced.

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A procedure for model building is described that combines morphing a model to match a density map, trimming the morphed model and aligning the model to a sequence.

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The functionality of the molecular-replacement pipeline phaser.MRage is introduced and illustrated with examples.
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