The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop

The crystal structure of human aldose reductase in complex with citrate at 0.82 Å resolution simultaneously shows the closed and open conformations of the safety belt. The two conformations correlate with different binding modes of the ligand.

Structure determination of the O-methyltransferase NovP using the `free lunch algorithm' as implemented in SHELXE

The crystal structure of NovP, an O-methyltransferase comprising 262 amino acids, was solved by SIRAS using 1.35 Å native data and 2.45 Å data from a single mercury derivative using a combination of partial chain tracing by hand of the initial very noisy map followed by data extrapolation to 1.0 Å resolution.