Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights

G. Róna, M. Marfori, M. Borsos, I. Scheer, E. Takács, J. Tóth, F. Babos, A. Magyar, A. Erdei, Z. Bozóky, L. Buday, B. Kobe and B. G. Vértessy

Nucleocytoplasmic trafficking of dUTPase, an enzyme essential for DNA integrity, is regulated by phosphorylation. The mechanism underlying this control is revealed by three-dimensional structures and cellular investigations.

Keywords: nuclear import; phosphorylation; nuclear localization signal; dUTPase; importin.

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