Structure and enzymatic mechanism of a moonlighting dUTPase

Horizontal gene transfer in some Staphyloccal phages is regulated by phage dUTPases, which are also responsible for maintaining genome integrity. Insights into the molecular mechanism of this regulation as well as into the enzymatic action of Φ11 phage dUTPase is provided by three-dimensional structural and enzyme kinetics studies.

Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights

Nucleocytoplasmic trafficking of dUTPase, an enzyme essential for DNA integrity, is regulated by phosphorylation. The mechanism underlying this control is revealed by three-dimensional structures and cellular investigations.