Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes

Y. K. Kim, M.-J. Kwak, B. Ku, H.-Y. Suh, K. Joo, J. Lee, J. U. Jung and B.-H. Oh

The crystal structure of the SOCS2-elongin BC-Cul5(1-386) complex explains the specificity of Cul2 and Cul5 for elongin BC and their preferential association with Cul2 or Cul5 box-containing proteins.

Keywords: Cullin-RING ubiquitin ligases; SOCS2-elongin BC-Cul2/Cul5 complex; molecular assembly; intersubunit recognition.

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