High-resolution structures of AidH complexes provide insights into a novel catalytic mechanism for N-acyl homoserine lactonase

A. Gao, G. Mei, S. Liu, P. Wang, Q. Tang, Y. Liu, H. Wen, X. An, L. Zhang, X. Yan and D. Liang

Crystal structures of the AHL-lactonase AidH in complex with substrate and product are reported at high resolution and a catalytic mechanism is proposed for the metal-independent AHL-lactonase.

Keywords: quorum sensing; lactonases; α/β-hydrolases; acid–base catalysis; covalent catalysis.

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