research papers
Natural dendocarbin A is a sesquiterpene lactone isolated from Drimys winteri. X-ray crystal structure analysis confirmed the S/R character of the chiral centres at C-5/C-10 and C-9/C-11, respectively. The α-OH group at C-11 was found to be involved in intermolecular hydrogen bonding, defining chains along the <100> 21 screw axis.
research papers
In the crystal structure of the natural compound hobartine, a tetracyclic alkaloid isolated from Aristotelia chilensis, the supramolecular structure in strongly related to the twofold screw axis, around which isolated chains build up, internally linked by an N—HN hydrogen bond which is the only significant intermolecular interaction present in the structure.
research papers
A cocrystal, obtained from Drimys winteri, is composed of two isomeric drimane sesquiterpene lactones, namely valdiviolide and 11-epivaldiviolide, neither of which has been reported in the crystal form. Both diastereoisomers present three chiral centres at sites 5, 10 and 11, with an SSR sequence in (Ia) and an SSS sequence in (Ib).