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The asymmetric unit of the title compound, C26H25ClN2O3, contains two independent mol­ecules (A and B). The conformation of the two mol­ecules differs essentially in the dihedral angle involving the two benzene rings. They are inclined to one another by 52.47 (10) in A and by 31.75 (11)° in B. In both mol­ecules, the six-membered piperidin-3-one rings have chair conformations. In mol­ecule A, all four five-membered rings have twist conformations. In mol­ecule B, only three of the four five-membered rings have twist conformations. The fourth, of the inden-1-one moiety, has an envelope conformation with the spiro C atom, bonded to the N atom of the pyrrolidine ring, as the flap. A weak intra­molecular O—H...N hydrogen bond occurs in each independent mol­ecule while a C—H...O inter­action is also observed in mol­ecule A. In the crystal, pairs of O—H...O hydrogen bonds link the mol­ecules, forming inversion dimers with graph-set motif R22(12). These dimers are further inter­connected by C—H...O and C—H...π inter­actions, forming a three-dimensional network.

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The title compound comprises a 2-imino­pyridine ring fused with a cyclo­octane ring, which adopts a twist boat–chair conformation. Inter­molecular C—H...N inter­actions form R_{2}^{2}(14) ring motifs and mol­ecules are further connected by weak C—H...π inter­actions.

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The asymmetric unit of the title compound, C19H16N2O5S, contains four independent mol­ecules (A, B, C and D), with two mol­ecules (B and D) displaying disorder in their methyl­sulfanyl groups [occupancy ratios of 0.797 (11):0.203 (11) and 0.85 (2):0.15 (2)]. The nitro groups are twisted slightly out of the planes of the 2-pyrroline rings to which they are bonded with dihedral angles of 10.17 (1), 8.01 (1), 9.44 (1) and 8.87 (1)° in mol­ecules A, B, C and D, respectively. The 2-pyrroline rings are almost orthogonal to the attached tolyl rings, forming dihedral angles of 73.44 (1), 81.21 (1), 88.18 (8) and 73.94 (1)° for mol­ecules A, B, C and D, respectively. A weak intra­molecular O—H...O inter­action is observed in mol­ecules B and C. The two hy­droxy groups in each mol­ecule are involved in inter­molecular O—H...O hydrogen bonding. In the crystal, mol­ecules are connected via O—H...O and C—H...O hydrogen bonds, forming a complex three-dimensional network.

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Two isotypic title compounds comprise a 2-imino­pyridine ring fused with a cyclo­octane ring. In one compound, the cyclo­octane ring adopts a twisted chair–chair conformation, while in the second, this ring adopts a twisted boat–chair conformation.

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In the title compound, the cyclo­octene ring adopts a twist chair-chair conformation. No directional inter­actions could be identified in the crystal and the packing is governed by van der Waals inter­actions.

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The title compound comprises a 2-amino­pyridine ring fused with a cyclo­heptane ring, which adopts a chair conformation. In the crystal, mol­ecules are linked via pairs of N—H...Nnitrile hydrogen bonds, forming inversion dimers which enclose R_{2}^{2}(14) ring motifs

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In the title compound C21H17N5O4·C2H6OS, the central six-membered ring derived from 1,4-di­hydro­pyridine adopts a distorted boat conformation with a small puckering amplitude of 0.127 (3) Å. The sums of bond angles around the pyridine N atom [358.7 (2)°] and the other imidazolidine N atom [60 (2)°] indicate that these atoms are in sp2 hybridization, leading to an essentially planar imidazolidine ring. The last heterocycle, an oxindole moiety, is also nearly planar with an r.m.s. deviation of 0.0185 (1) Å. The amine NH2 group forms an intra­molecular hydrogen bond with the benzoyl group, giving a S(6) motif. In the crystal, N—H...O hydrogen bonds lead to the formation of chains along the c-axis direction. Within the chains there are further N—H...O and C—H...O hydrogen bonds enclosing R22(14) ring motifs. The chains are linked via N—H...O and C—H...O hydrogen bonds involving the dimethyl sulfoxide solvent mol­ecule which acts as both an acceptor and a donor..

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In the title compound, C20H22N2O2, the central pyridine ring forms a dihedral angle of 76.32 (8)° with the pseudo-axial benzene ring. The cyclo­octane ring adopts a twisted boat chair conformation. In the crystal, weak inter­molecular C—H...π inter­actions between inversion-related mol­ecules result in the formation of linear double chains along the b-axis direction.

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In the title compound, C22H18BrN5O4, the central six-membered ring, derived from 1,4-di­hydro­pyridine, adopts a distorted boat conformation with a puckering amplitude of 0.197 (3) Å, the imidazole ring adopts a twisted conformation with a puckering amplitude of 0.113 (3) Å, and the oxindole moiety is planar with an r.m.s. deviation of 0.0125 Å. Two intra­molecular N—H...O hydrogen bonds are formed, each closing an S(6) loop. In the crystal, strong N—H...O hydrogen bonds lead to the formation of zigzag chains along the c axis. These are consolidated in the three-dimensional crystal packing by weak N—H...O hydrogen bonding, as well as by C—H...O, C—H...Br and C—H...π inter­actions. A small region of electron density well removed from the main mol­ecule was removed with the SQUEEZE procedure in PLATON [Spek (2009). Acta Cryst. D65, 148–155] following unsuccessful attempts to model it as a plausible solvent mol­ecule. The unit-cell characteristics do not take into account this feature of the structure.

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In the title compound, C19H19FN2O, the cyclo­octene ring adopts a twisted boat-chair conformation. The dihedral angle between the plane of the fluorophenyl substituent and that of the pyridine ring is 76.39 (8)°. The F and ortho-H atoms of the fluoro­benzene ring are disordered, with occupancy factors of 0.226 (5) and 0.774 (5). In the crystal, no significant inter­actions are observed between the mol­ecules beyond van der Waals contacts.

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The asymmetric unit of the title compound, C21H15Cl2N5O4, contains two independent mol­ecules (A and B) having similar conformations. The amine (NH2) group forms an intra­molecular hydrogen bond with the benzoyl group, giving an S(6) ring motif in both mol­ecules. The central six-membered rings adopt sofa conformations and the imidazole rings are planar (r.m.s deviations = 0.0150 and 0.0166 Å). The pyridine and imidazole rings are inclined to one another by 3.54 (1) and 3.03 (1)° in mol­ecules A and B, respectively. In the crystal, mol­ecules are linked by N—H...O hydrogen bonds, forming chains along the a axis which enclose R22(16) ring motifs. The rings are linked by weak N—H...O and C—H...O hydrogen bonds and C—H...π inter­actions forming sheets lying parallel to (001). A region of disordered electron density, most probably disordered solvent mol­ecules, occupying voids of ca 753 Å3 for an electron count of 260, was treated using the SQUEEZE routine in PLATON [Spek (2009). Acta Cryst. D65, 148–155]. Their formula mass and unit-cell characteristics were not taken into account during refinement.

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In the title compound, C24H14Cl2N2O2S, the 2H-chromene ring system is approximately planar, with a maximum deviation of 0.025 (2) Å. The thia­zole ring is almost planar, with an r.m.s. deviation of 0.0022 Å, and makes a dihedral angle of 58.52 (7)° with the chromene ring system. The chromene ring system is inclined at angles of 58.3 (1) and 55.39 (9)° with respect to the two chloro­phenyl rings. The two chloro­phenyl rings show significant deviation from coplanarity, with a dihedral angle between them of 47.69 (8)°. The crystal structure features C—H...Cl inter­actions extending in (100) and propagating along the a-axis direction and weak π–π inter­actions [centroid–centroid separation = 3.867 (2) Å].
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