organic compounds
Open access
In an endeavor directed towards the construction of the oxabicyclic[3.2.1]octane segment present in the bioactive natural products of cortistatins and icetexanes genre, the title compound, C13H19BrO3, was synthesized from (4aR,9aS)-1,3,4,4a,5,6,9,9a-octahydrospiro[benzo[7]annulene-2,2′-[1,3]dioxolane]-4a-ol via a transannular bromo-etherification protocol. The six-membered ring adopts a twist-boat conformation, while the fused cycloheptane ring adopts a chair conformation. The crystal packing is effected through two distinct intermolecular C—HO hydrogen-bond patterns and molecules are arranged to define an interesting motif along the b axis.