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The title compound, C19H18O5, is a diastereoisomer of crotocaudin, both being isolated from the plants of genus Croton. In isocrotocaudin, the furan moiety makes a dihedral angle with the adjacent lactone of 13.53 (17)°. The cyclo­hexyl ring of the diterpene moiety adopts a chair confirmation. The weak intermolecular C—H...O hydrogen bonds link the mol­ecules into linear chains along the c axis.
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