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In the title compound, C32H28F2N2O2, the tetra­hydro­pyridine ring adopts a distorted boat conformation. The two fluoro­phenyl groups are attached to the tetra­hydro­pyridine ring in a trans orientation. The dihedral angle between the planes of the fluoro-substituted rings is 57.0 (1)°. The amino group and carbonyl O atom are involved in intra­molecular hydrogen bonding. In the crystal, weak C—H...O, C—H...F and C—H...π inter­actions link the mol­ecules into columns along [010].

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In the title mol­ecule, C31H24F4N2O2, the tetra­hydro­pyridine ring adopts a distorted boat conformation. An intra­molecular N—H...O hydrogen bond is formed by the amino group and ccarboxyl C=O atom. The crystal structure features weak C—H...F and C—H...O inter­actions.

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In the title mol­ecule, C34H32Cl2N2O2, the tetra­hydro­pyridine ring adopts a distorted boat conformation and both 4-chloro­phenyl substituents are in axial positions. An intra­molecular N—H...O hydrogen bond is formed by the amino group and carbonyl O atom. In the crystal, weak C—H...Cl inter­actions link the mol­ecules into chains along [010].

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In the title compound, C13H12O5, the mean plane of the 2H-chromene ring system (r.m.s deviation = 0.026 Å) forms a dihedral angle of 81.71 (6)° with the mean plane of ethyl 2-hy­droxy­acetate moiety (r.m.s deviation = 0.034 Å). In the crystal, C—H...O hydrogen bonds result in the formation of zigzag layers parallel to the bc plane.

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In the title compound, C14H17N3O2, the mean plane of the 1,8-naphthyridine ring system (r.m.s deviation = 0.020 Å) forms a dihedral angle of 23.4 (1)° with the acetamide moiety (r.m.s deviation = 0.001 Å). The mol­ecular structure is stabilized by an intra­molecular O—H...N hydrogen bond, which generates an S(5) ring motif. In the crystal, mol­ecules are linked into inversion dimers by pairs of N—H...O hydrogen bonds, generating 18-membered R22(18) ring motifs.

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In the title compound, C32H26Cl2F2N2O2, the tetra­hydro­pyridine ring adopts a distorted boat conformation. The chlorophenyl rings are inclined to one another by 55.2 (1)°, while for the fluorophenyl rings the dihedral angle is 80.7 (1)°. The amino group and carbonyl O atom are involved in an intra­molecular N—H...O hydrogen bond. In the crystal, weak C—H...O, C—H...F and C—H...Cl inter­actions link the mol­ecules into a three-dimensional network.

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The title compound, C19H19N5O5·3.5H2O, crystallizes with 3.5 mol­ecules of water in the asymmetric unit, one of which lies on a mirror plane. One of the water mol­ecules links the mol­ecules, forming centrosymmetric dimers. These dimers are then linked through further N—H...O and O—H...O hydrogen bonding, leading to the observed three-dimensional structure.
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