The application of hybrid pixel detectors for in-house SAXS instrumentation with a view to combined chromatographic operation

Home-source small-angle X-ray scattering (SAXS) data acquired using a hybrid pixel single-photon-counting detector is presented. The radius of gyration, maximum dimension and the molecular mass of protein complexes can be obtained at the short exposure times and relatively low protein concentrations necessary for size-exclusion chromatography integration.