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The Ni atom in the title compound, [Ni(C20H38N4O4)]·4H2O, is chelated by four N atoms of the macrocycle and also covalently bonded to two carboxyl­ate groups, in a cis-N4O2Ni octa­hedral environment. The mononuclear complex inter­acts with the solvent water mol­ecules to form a three-dimensional network structure.
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