Direct methods and simulated annealing: a hybrid approach for powder diffraction data

The procedure implemented in a previous version of EXPO combining a Monte Carlo approach with the information contained in the Fourier map as obtained at the end of a direct-methods procedure has been revised and improved.

Ab initio phasing of proteins with heavy atoms at non-atomic resolution: pushing the size limit of solvable structures up to 7890 non-H atoms in the asymmetric unit

New algorithms have been devised to attempt ab initio protein crystal structure solution for data resolutions of up to 2 Å.